Suggestions by @samualgregory

Michael Bay

as Director in The binding of isaac (Movie DLC)

RuPaul

as The Siren in The binding of isaac (Movie DLC)

Tom Hanks

as Satan/Mega Satan in The binding of isaac (Movie DLC)

Leonardo DiCaprio

as The Lamb in The binding of isaac (Movie DLC)

Neil Patrick Harris

as Rainmaker in The binding of isaac (Movie DLC)

Morgan Freeman

as Father in The binding of isaac (Movie DLC)

Lizzo

as Mother in The binding of isaac (Movie DLC)

Seth Rogen

as Monstro in The binding of isaac (Movie DLC)

Kevin Hart

as Gemini (Small) in The binding of isaac (Movie DLC)

Dwayne Johnson

as Gemini (Big) in The binding of isaac (Movie DLC)

Dwayne Adway

as Gemini (big) in The binding of isaac (Movie DLC)

Danny DeVito

as Duke of Flies in The binding of isaac (Movie DLC)

Jonah Hill

as Esau in The binding of isaac (Movie DLC)

Michael Cera

as Jacob in The binding of isaac (Movie DLC)

Ella Purnell

as Bethany in The binding of isaac (Movie DLC)

Kieran Culkin

as The Soul in The binding of isaac (Movie DLC)

Macaulay Culkin

as The Forgotten in The binding of isaac (Movie DLC)

Jim Carrey

as Apollyon in The binding of isaac (Movie DLC)

Jim Carrey

as Apollyon in The binding of isaac (Movie DLC)

Jim Calvert

as Apollyon in The binding of isaac (Movie DLC)