Suggestions by @samualgregory

Josh Gad

as Keeper in The binding of isaac (Movie DLC)

Jackie Chan

as Liliths Incubus/Fetus in The binding of isaac (Movie DLC)

Danielle Brooks

as Lilith in The binding of isaac (Movie DLC)

Giancarlo Esposito

as Lost in The binding of isaac (Movie DLC)

Millie Bobby Brown

as Eden in The binding of isaac (Movie DLC)

Ed Sheeran

as Lazarus in The binding of isaac (Movie DLC)

Ben Schwartz

as Azazel in The binding of isaac (Movie DLC)

Keanu Reeves

as Samson in The binding of isaac (Movie DLC)

Awkwafina

as Eve in The binding of isaac (Movie DLC)

Lazy Matt man

as Blue Baby in The binding of isaac (Movie DLC)

Mark Wahlberg

as Judas in The binding of isaac (Movie DLC)

Johnny Depp

as Cain in The binding of isaac (Movie DLC)

Magda Szubanski

as Magdalene in The binding of isaac (Movie DLC)

J.K. Simmons

as Isaac in The binding of isaac (Movie DLC)