A group of outcast superheroes - Robotman, Negative Man, Elasti-Girl and Crazy Jane - led by the mysterious Dr. Niles Caulder, also known as “The Chief”, all find their purpose as a dysfunctional support group and superhero team, investigating bizarre phenomena while dealing with their own traumas and disfigurements from accidents that gave them their powers, often stepping up to save the world from existential crises, including protecting Caulder’s reality-bending daughter Dorothy Spinner.