When a heist gone wrong exposes young mutants Remy Lebeau and Belladonna Boudreaux as superpowered outlaws, their rival New Orleans crime families erupt into a bloody decade-long war. Remy’s surrogate father is murdered, and he is cast out, becoming a reckless international thief. Years later, the enigmatic geneticist Nathaniel Essex offers Remy forty million dollars to steal back a mysterious trunk from Belladonna’s mother—a job that forces Remy to reunite with his estranged crew, reconcile with Bella, and infiltrate the legendary Thieves Ball. But the trunk contains a terrifying secret that ties Remy’s own dark origins to Essex’s sinister mutant-breeding compound, forcing Remy to choose between revenge, redemption, and the family he lost.