Charlotte A. Cavatica is the titular deuteragonist of E.B. White's book Charlotte's Web and both of its film adaptions. She is a barn spider that befriends a pig named Wilbur and does everything she can to save him from being slaughtered.
Obviously, don't nominate any human characters. Hybrids like Cheetah or The Lizard are okay, as are shapeshifters with one set animal form (eg Professor McGonagall.)