Suggestions by @willsheffield

Alyson Hannigan

as Jane Jetson in The Jetsons (Live Action)

Tim Robinson

as George Jetson in The Jetsons (Live Action)

Henry Golding

as Brainiac in Casting James Gunn's DCU! :D

Linda Cardellini

as Cheetah in Casting James Gunn's DCU! :D

Cillian Murphy

as Black Mask in Casting James Gunn's DCU! :D

Nicholas Braun

as Two Face in Casting James Gunn's DCU! :D

Jane Levy

as Poison Ivy in Casting James Gunn's DCU! :D

Mia Goth

as Harley Quinn in Casting James Gunn's DCU! :D

Patrick Warburton

as Jor-El in Casting James Gunn's DCU! :D

Andre Braugher

as Gorilla Grodd in James Gunn’s DC Supervillains

Michael Jai White

as Bronze Tiger in James Gunn’s DC Supervillains

Oleg Taktarov

as KGBeast in James Gunn’s DC Supervillains

Nick Zano

as Kite Man in James Gunn’s DC Supervillains

Tom Cruise

as Catman in James Gunn’s DC Supervillains

Amadeus Serafini

as Killer Moth in James Gunn’s DC Supervillains

John Tui

as Maxie Zeus in James Gunn’s DC Supervillains

David Tennant

as Calendar Man in James Gunn’s DC Supervillains

India de Beaufort

as Talia al Ghul in James Gunn’s DC Supervillains

Matthew Lillard

as Man-Bat in James Gunn’s DC Supervillains

Adam Pally

as Hush in James Gunn’s DC Supervillains