Suggestions by @themegacaster

Zeus (Disney)

as Who beat Thanos (Final Level) in Who could fight Thanos in hand-to-hand combat?

Knuckles the Echidna

as Who beat Thanos (Level Three) in Who could fight Thanos in hand-to-hand combat?

Mega Man X

as Who beat Thanos (Level 5) in Who could fight Thanos in hand-to-hand combat?

Mega Man X

as Non-tendo Video Game(s) in Who could fight Thanos in hand-to-hand combat?

Aang

as Who beat Thanos (Final Level) in Who could fight Thanos in hand-to-hand combat?

Donkey Kong (Character)

as Who beat Thanos (Level Three) in Who could fight Thanos in hand-to-hand combat?

Plastic Man (Patrick O’Brian)

as Who beat Thanos (Level 5) in Who could fight Thanos in hand-to-hand combat?

Lobo (DC)

as Who beat Thanos (Level Three) in Who could fight Thanos in hand-to-hand combat?

Doomsday

as Who beat Thanos (Final Level) in Who could fight Thanos in hand-to-hand combat?

Bugs Bunny

as Who beat Thanos (Level Three) in Who could fight Thanos in hand-to-hand combat?

Samurai Jack (Character)

as Who beat Thanos (Level Three) in Who could fight Thanos in hand-to-hand combat?

Sonic the Hedgehog (Character)

as Who beat Thanos (Level Three) in Who could fight Thanos in hand-to-hand combat?

Batman (Bruce Wayne)

as Who beat Thanos (Level Three) in Who could fight Thanos in hand-to-hand combat?

Superman (Clark Kent/Kal-El)

as Who beat Thanos (Final Level) in Who could fight Thanos in hand-to-hand combat?

Hades (Disney)

as Villains in Who could fight Thanos in hand-to-hand combat?

Aku (Samurai Jack)

as Villains in Who could fight Thanos in hand-to-hand combat?

Mega Man

as Non-tendo Video Game(s) in Who could fight Thanos in hand-to-hand combat?

Mega Man

as Who beat Thanos (Level 5) in Who could fight Thanos in hand-to-hand combat?

Darkseid

as Who beat Thanos (Final Level) in Who could fight Thanos in hand-to-hand combat?

Vegeta

as Who beat Thanos (Final Level) in Who could fight Thanos in hand-to-hand combat?