Suggestions by @skytalk

Gordon Cormier

as Papa Song Punk in Cloud Atlas (2028)

John Hoogenakker

as Haskell Moore's Dinner Guest / Jarvis Hoggins in Cloud Atlas (2028)

Nicholas Podany

as Haskell Moore's Dinner Guest / Eddie Hoggins in Cloud Atlas (2028)

Nancy Jewel McDonie

as Megan Sixsmith / 12th Star Clone in Cloud Atlas (2028)

Gillian Anderson

as Haskell Moore's Dinner Guest / Nurse Judd / Aide in Slaughtership in Cloud Atlas (2028)

Josh Peck

as Haskell Moore's Dinner Guest / Musician / Felix Finch / Lascivious Businessman in Cloud Atlas (2028)

Eli D Goss

as Javier Gomez / Jonas / Zachry's Older Nephew in Cloud Atlas (2028)

Daniel Brühl

as Mr. Boerhaave / Guard / Leary the Healer in Cloud Atlas (2028)

Poppy Liu

as Talbot (Hotel Manager) / Yoona-939 / Rose in Cloud Atlas (2028)

Joe Alwyn

as Young Rufus Sixsmith / Old Rufus Sixsmith / Nurse James / Archivist Park in Cloud Atlas (2028)

Omar Benson Miller

as Kupaka / Joe Napier / An-kor Apis / Prescient in Cloud Atlas (2028)

Kelvin Harrison Jr.

as Autua / Lester Rey / Duophsyte in Cloud Atlas (2028)

Demi Moore

as Madame Horrox / Older Ursula / Yusouf Suleiman / Abbess in Cloud Atlas (2028)

Josh Hartnett

as Rev. Giles Horrox / Hotel Heavy / Lloyd Hooks in Cloud Atlas (2028)

May Hong

as Tilda Ewing / Megan's Mom / Mexican Woman / Sonmi-451 / Sonmi-351 / Sonmi P in Cloud Atlas (2028)

Harris Dickinson

as Adam Ewing / Poor Hotel Guest / Megan's Dad in Cloud Atlas (2028)

John C. Reilly

as Captain Molyneux / Vyvyan Ayrs / Timothy Cavendish / Korean Musician / Prescient in Cloud Atlas (2028)

Lupita Nyong'o

as Native Woman / Jocasta Ayrs / Luisa Rey / Indian Party Guest / Ovid / Meronym in Cloud Atlas (2028)

Adrien Brody

as Dr. Henry Goose / Hotel Manager / Isaac Sachs / Dermot Hoggins in Cloud Atlas (2028)

Natalie Portman

as Young Ursula in Cloud Atlas (2002)