Suggestions by @mr_blue_sky

Jamie Lee Curtis

as Franny Goldsmith in George Romero's The Stand (1983)

Harrison Ford

as Stu Redman in George Romero's The Stand (1983)

Robert Duvall

as Randall Flagg in George Romero's The Stand (1983)

Kelly McGillis

as Vicki McGee in John Carpenter’s Firestarter (1983)

Burt Lancaster

as Captain Richard Hollister in John Carpenter’s Firestarter (1983)

Barbara Bach

as Dr. Roberta Rahz in John Carpenter’s Firestarter (1983)

Vinnie Jones

as Rhino in Spider-Man 11

Ben Stiller

as The Shocker in Spider-Man 11

Ben Foster

as Electro in Spider-Man 11

Danny Glover

as Puppet Master in Fantastic Four 4 (2012)

Alan Tudyk

as Chameleon in Spider-Man 5 (2011)

Oliver Reed

as Beast in Spider-Man '77

André Roussimoff

as Blockbuster in Batman '66 Villains

Melissa Gilbert

as Mary Jane Watson in Spider-Man '77: The Hobgoblin Strikes

Shaun Cassidy

as Harry Osborn in Spider-Man '77: The Hobgoblin Strikes

Nicholas Hammond

as Spider-Man in Spider-Man '77: The Hobgoblin Strikes

John Rhys-Davies

as Kingpin in Spider-Man '77: The Hobgoblin Strikes

Hilly Hicks

as Robbie Robertson in Spider-Man '77: The Hunter and the Hunted

Jamie Lee Curtis

as Betty Brant in Spider-Man '77: The Hunter and the Hunted

Jeff Donnell

as Aunt May Parker in Spider-Man '77: The Hunter and the Hunted