Suggestions by @mr_blue_sky

Danny DeVito

as Tinkerer in Spider-Man (The Series)

Cillian Murphy

as Chameleon in Spider-Man (The Series)

Jeremy Irons

as Vulture in Spider-Man (The Series)

Aaron Eckhart

as The Lizard in Spider-Man (The Series)

Josh Brolin

as Sandman in Spider-Man (The Series)

Jamie Foxx

as Electro in Spider-Man (The Series)

Bokeem Woodbine

as Shocker in Spider-Man (The Series)

Michael Mando

as Scorpion in Spider-Man (The Series)

Mark Hamill

as Doctor Octopus in Spider-Man (The Series)

Willem Dafoe

as Green Goblin in Spider-Man (The Series)

Ernie Hudson

as Robbie Robertson in Spider-Man (The Series)

J.K. Simmons

as J. Jonah Jameson in Spider-Man (The Series)

Natalia Dyer

as Betty Brant in Spider-Man (The Series)

Justice Smith

as Randy Robertson in Spider-Man (The Series)

Olivia Rodrigo

as Sally Avril in Spider-Man (The Series)

Jacob Elordi

as Flash Thompson in Spider-Man (The Series)

Meg Donnelly

as Liz Allan in Spider-Man (The Series)

Jimmy Smits

as Ben Parker in Spider-Man (The Series)

Marisa Tomei

as May Parker in Spider-Man (The Series)

Zendaya

as Mary Jane Watson in Spider-Man (The Series)