Suggestions by @geekking97

Stanley Anderson

as General Slocum in Spider-Man (2002)

Elizabeth Banks

as Betty Brant in Spider-Man (1999)

Elizabeth Banks

as Betty Brant in Spider-Man (2002)

Jessica Biel

as Mercedes "Mercy" Graves in Superman (2013)

Billy Zane

as Lex Luthor in Superman (2013)

James Wolk

as Superman/Clark Kent in Superman (2013)

Octavia Spencer

as Check In Girl in Spider-Man (2013)

Dennis Farina

as J. Jonah Jameson in Spider-Man (2013)

Martin Sheen

as Ben Parker in Spider-Man (2013)

Lauren Cohan

as Victoria Hand in Spider-Man (2013)

Helen Mirren

as May Parker in Spider-Man (2013)

RJ Mitte

as Harry Osborn in Spider-Man (2013)

Emma Stone

as Mary Jane Watson in Spider-Man (2013)

Ciarán Hinds

as Otto Octavius/Doctor Octopus in Spider-Man (2013)

Jason Isaacs

as Norman Osborn/Green Gobin in Spider-Man (2013)

Dylan O'Brien

as Peter Parker/Spider-Man in Spider-Man (2013)

Stan Lee

as Stan Lee in Fantastic Four (2013)

Benedict Cumberbatch

as Victor Von Doom/Doctor Doom in Fantastic Four (2013)

Anthony Ingruber

as Han Solo in Star Wars: Episode IV - A New Hope (2010 Recast)

Jeremy Irons

as Darth Vader in Star Wars OT in early 90s