After the Avengers' emergence proves that superhumans can become celebrated global heroes, mutantkind finds itself facing a very different reality: fear, discrimination, and government scrutiny. When a powerful anti-mutant movement exploits a series of mutant-related incidents to push for worldwide registration and containment, Professor Charles Xavier sends the X-Men into action—only to discover that a mysterious mastermind is deliberately escalating the conflict between humans and mutants to ignite a war neither side can survive.