Years after the X-Men became the world's foremost protectors of mutantkind, rising anti-mutant fear erupts into a coordinated campaign of violence as the enigmatic Mister Sinister begins abducting mutants to advance a centuries-old genetic experiment. Forced to confront a conspiracy that reaches from the halls of government to the darkest corners of mutant history, Cyclops must unite a fractured team to protect Xavier's dream before Sinister unlocks the next stage of human evolution—one that could reshape the future of both mutants and humanity forever.