Happens after "Doctor Doom". Red Skull was freed from the Latverian super-prison he was in because of Madame Viper and what remains of Hydra, in order to create a weapon that will kill all mutants. The X-Men will have to come to light to save their "race" but also the rest of the world. To do so, the students of Professor X will meet for the first time, while they were doing research in Madripoor, Wolverine. This one will be able to give them news of Magneto and his whereabouts, in addition to facing an old enemy who knows part of his past with the Red Skull !