The series follows Sara Pezzini, a NYPD homicide detective who comes into possession of the Witchblade, a supernatural, sentient gauntlet that bonds with a female host and provides her with a variety of powers in order to fight supernatural evil. Sara struggles to hone the powers of the Witchblade and fend off those with a nefarious interest in it, such as entrepreneur Kenneth Irons and his bodyguard Ian Nottingham.
