In 1947 Los Angeles, animated cartoon characters, or "toons", co-exist with humans, often working as film stars. Private detective Eddie Valiant, once a staunch ally of the toons, has become a depressed alcoholic following his brother Teddy's murder by an unknown toon five years prior. Maroon Cartoon Studios owner R.K. Maroon, upset about the recent poor performance of his toon star Roger Rabbit, hires Eddie to investigate rumors that Roger's glamorous toon wife, Jessica, is having an affair with Marvin Acme, owner of both the Acme Corporation and Toontown, the animated metropolis in which toons reside.
