Set in the fictional and peaceful Fuzzytown, Carl the Collector centers on the life of Carl, an autistic child racoon with a special interest in creating collections of various items, and his friends. Carl's friends include Sheldon, a compassionate beaver and Carl's best friend; Lotta, a shy and autistic fox with an artistic talent and hypersensitivity to sound; Forrest, a hyperactive squirrel; and Nico and Arugula, identical twin bunny sisters with opposing personalities. Episodes often involve Carl and his friends working together and learning lessons to overcome new situations.