When a failed nuclear fusion experiment results in an explosion that kills his wife, Dr. Otto Octavius (Patton Oswalt) is transformed into Dr. Octopus, a cyborg with deadly metal tentacles. Doc Ock blames Spider-Man (Tom Holland) for the accident and seeks revenge. Meanwhile, Spidey's alter ego, Peter Parker, faces fading powers and self-doubt. Complicating matters are his best friend's (Timothee Chalamet) hatred for Spider-Man and his true love's (Meg Donnelly) sudden engagement to another man.
