A hard-drinking Texas preacher named Jesse Custer, possessed by a cosmic entity called Genesis that gives him the power to command anyone with his voice, hits the road with his ex-girlfriend Tulip and a degenerate Irish vampire named Cassidy to find the God who abandoned Heaven. Hunted by the Saint of Killers—an immortal, unstoppable gunfighter unleashed by terrified angels—Jesse must confront the monstrous family that murdered his father and forced him into the pulpit, culminating in a bloody showdown in the burning ruins of Annville where he finally breaks free of his past and demands answers from the divine.
