1903, three years after defeating the group of monsters led by Imhotep, Van Helsing and his family will face a new, even more terrible threat. A plot, led by a "man" in the shadows to help the Martian empire, or rather what's left of it, to dominate the Earth to make it a new Mars. To try to stop him, Van Helsing's team, warned by two monster hunters from France, the Phantom of the Opera and the Hunchback of Notre-Dame, will have to find the mysterious Doctor Moreau, who would have a weapon to defeat them. For his part, while he leads the "vampire nation" again, Dracula is attacked by an old acquaintance, calling herself "Bloody Mary", the latter being allied with the Martians and their accomplices. Whatever happens from now on, the existence of the "monsters" can no longer remain unknown to everyone, because a war of the worlds will soon begin... and all we can hope is that those who are rejected by society still manage to save us from darkness.
