After the devastating loss of Dakota Doyle and events of the Red Goblin incident, Spider-Man faces a new wave of threats in New York. Doctor Octopus emerges, building an army of robotic arms and dangerous tech. Meanwhile, a new symbiote threat, Riot inside was Eugene Thames, surfaces, forcing Spider-Man to face both human and symbiotic dangers. Unexpectedly, Dylan Brock become Venom joins the fight, helping Spider-Man battle the chaos while uncovering Doctor Octopus’ sinister plans.