A group of misguided animal rights activists free a caged chimp infected with the "Rage" virus from a medical research lab. When Stilport bike courier Jared (Kerr Smith) wakes up from a coma a month after, he finds his city all but deserted. On the run from the zombie-like victims of the Rage, Jared stumbles upon a group of survivors, including Sawyer (Anika Noni Rose) and cab driver Finn (Mark Hamill), and joins them on a perilous journey to what he hopes will be safety.