When a failed nuclear fusion experiment results in an explosion that kills his wife, Dr. Ben Solo (Adam Driver) is transformed into Dr. Kylo Ren, a cyborg with deadly metal tentacles. Kylo Ren blames Spider-Man (Joseph Gordon-Levitt) for the accident and seeks revenge. Meanwhile, Spidey's alter ego, Jim Hawkins, faces fading powers and self-doubt. Complicating matters are his best friend's (Jason Lee) hatred for Spider-Man and his true love's (Meg Ryan) sudden engagement to another man.