The fifth installment of the popular franchise focuses on Madison (Amy Sedaris), a survivor of the fourth, who believes Eddie Brock / Venom (Michael Keaton) has been eliminated for good. She optimistically hopes to start a life with fellow survivor Dylan (Matt Dillon). The nightmares begin soon enough, though, and Madison learns she is pregnant. When her friends start dying, Madison suspects that Venom is using the fetus within her as a weapon. Can she fight the demon while protecting her unborn child?