Taking place between Uncharted 2 and 3, Nathan Drake once again finds himself on a trek across the world to find a long lost artifact: The Spear of Destiny. Supposedly the spear that pierced the side of Jesus Christ grants those that wield it immense and great power; either to heal, destroy, or control the world and its people. A spear that even the Nazis wanted back in World War 2 and almost had.
Now, Nathan Drake, Elena Fisher, Victor Sullivan, Chloe Frazer, and a new ally Charlie Cutter, must race across the world, new exotic locations, even walk in Jesus's path as they race against an infamous paramilitary owner and his band of mercenaries.