The title character, Top Cat (T.C.), is the leader of a gang of Manhattan alley cats living in Hoagy's Alley: Fancy-Fancy, Spook, Benny the Ball, Brain, and Choo-Choo.
The gang constantly hatch get-rich-quick schemes through scams but they usually backfire, and a frequent plot thread revolves around the local police officer, Charles "Charlie" Dibble (voiced by Allen Jenkins), ineffectually trying to either arrest them, evict them from the alley, get them to clean the alley, or stop them using the policebox phone.