Set after the events of Tom & Jerry and Tom & Jerry in New York (2021), Ben receives a bill for both weddings. Tom and Jerry reunited with his long-lost friend, a street cat named Tad, before being forced into joining him on a high-eneimes adventure. An ten-year-old girl named Christina Anderson, who enlists Tom and Jerry's help to escape from her personal sorceress named Bradford Hendricks and reunite with her lost and presumed-dead mother and father as they to Miami after believing that Terrence, Spike Bulldog, Toots, and Goldfish and the gang will propose to his girlfriend, Xandra. After an two cat, mouse and tries to domain against to NYC and Florida, but it's up to Tom, Jerry, Tad, Kayla and Christina to stop him.
