Soon after the events of A Day of Judgement, botanist Wilfred Glendon brings two things home to London: first, a bite from a werewolf (not from Larry Talbot), and three specimens of an extremely rare flower known as mariphasa lupine lumina. Glendon embarks on a trip to find his former friend, now known to the world as The Wolf Man, fearing that a werewolf epidemic could rise if Larry isn't given something to control his curse. But when he turns into a werewolf and murders a young woman, he enlists his wife Lisa, her best friend, the mysterious Doctor Warner Yogami, and Larry Talbot himself....but can Wilfred control his curse?