The series is set in the fictional town of Mystic Falls, Virginia, a town charged with supernatural history. It follows the life of Enis Gilbert, a teenage boy who has just lost both parents in a car crash, as he falls in love with a 161-year-old vampire named Sophia Salvatore, who he thinks is just a normal human. Their relationship becomes increasingly intricate as Sophia's mysterious older sister Dana Salvatore returns to Mystic Falls with a plan to bring back their past love, Kevin Pierce, who is Enis's doppelgänger.