Following the energy shock caused by Thanos' Blip, a new race of more evolved humans called "mutants" officially appears. Public opinion then begins to rise against them, fearing that they seek to dominate humanity, particularly because of the recent events involving Wanda Maximoff whose mutant nature has been exposed.
Charles Xavier, one of the first mutants whose telepathic powers had manifested since childhood, uses Cerebro to find and recruit mutants in his Westchester mansion that he has been trying to open, in vain so far. He recruits Scott Summers, Jean Grey, Bobby Drake, Ororo Munroe and Kurt Wagner to help them master their powers. Meanwhile, an old friend of Xavier's, Erik Lensherr returns to the outside world after several decades spent in his lair on M Island. Having heard of the new wave of mutants that has spread throughout the world, Erik also recruits other mutants to create his brotherhood composed of Mystique, Toad, Pyro and the Blob.
In order to overcome the mutant problem, the government calls on the services of Dr. Bolivar Trask who creates a new series of robots inspired by Stark Industries technology : the Sentinels, designed to target and track mutants.
