Six months after what the news has named the "Cat Fight Debacle", Thea Stilton returns to her alma mater, the prestigious Mouseford Academy, to be an archaeology professor. It is here where she meets five female students with whom she quickly bonds. However, the team soon has to go on a globetrotting adventure to solve the thefts of several historical artifacts by unscrupulous archaeologist Paco Manadunca.
