When brilliant college student Peter Parker is bitten by a genetically altered spider, he discovers superhuman abilities—strength, agility, and a Spider-Sense—that connect him to New York City like never before. As he tries to balance his academic life with the responsibility of protecting the innocent, he's drawn into a conflict that threatens to destroy the city: Doctor Octopus, his college professor, has formed a group of villains known as the Sinister Six—Rhino, Electro, Vulture, Shocker, Scorpion, and himself—to overthrow Norman Osborn for personal reasons, dragging Peter into the fight of his life.
Between complicated romances with Mary Jane Watson and personal tragedies that will mark his path, Peter must learn that being a hero doesn't just mean having power, but also making sacrifices that could cost him what he loves most. With relentless enemies, moral dilemmas, and the shadow of his family's past, Spider-Man faces his ultimate test: can a young college student become a hero without losing himself in the process?
