Mephisto is a fictional character appearing in American comic books published by Marvel Comics. The character first appeared in Silver Surfer #3 (December 1968),[2] and was created by Stan Lee and John Buscema and based on Mephistopheles: a demon character from the Faust legend, who has sometimes been referred to as Mephisto. Introduced as a recurring adversary of the Silver Surfer and Ghost Rider (Johnny Blaze), Mephisto has also endured as one of Spider-Man's most prominent adversaries, being responsible for Norman and Harry Osborn's respective transformations into the Green Goblin and Kindred; and for the superhero's loss of his marriage to Mary Jane Watson, considering their future daughter Spider-Girl his archenemy. The father of Blackheart, Jezebel, and Father Priest, Mephisto has often come into conflict with Doctor Strange, Doctor Doom, Scarlet Witch and other heroes of the Marvel Universe, being responsible both for the creation of the Cosmic Ghost Rider and the descents of the Osborns, Phil Coulson, and Otto Octavius into villainy. Debuting in the Silver Age of comic books, Mephisto has appeared in over five decades of Marvel continuity. The character has also appeared in associated Marvel merchandise, including animated television series, feature film, toys, trading cards, and video games. Mephisto has been described as one of Marvel's most notable and powerful supervillains.[3][4][5][6][7] In the two Sony Pictures–produced Ghost Rider films, Mephisto was first portrayed by Peter Fonda in Ghost Rider (2007) and then by Ciarán Hinds in Ghost Rider: Spirit of Vengeance (2012), and more recently by Sacha Baron Cohen in the Marvel Cinematic Universe (MCU) Disney+ miniseries Ironheart (2025).