Cady joins a new public school and befriends Janis and Damian. They warn her to avoid the Plastics, a group led by Regina, but things get worse when she falls in love with Aaron, Regina's ex-lover.
An adult animated series about set in 2005-2006 about to three unpopular best friends of different race at an all-male university who face racism, sexuality and drug until they form an anti-girl and drug dealer club. But the goal fails when the founder and the club's leader falls in love with the cute cheerleader of the club's rival sorority.