It's been 3 months ever since the death of Gwen Stacy. Peter has fully tapped into his anger and has been agressivily taking it out on the crimanls. Harry is still greiving the death of his father, Norman Osborn at the hands of Spider-Man. Peter told Harry he was Spider-Man, which was a mistake. Due to his anger being fully 10 fold, Peter gets in contact with the symbiote.
