David Spade hosts "Snake Oil," a game show that challenges contestants to choose a pair of entrepreneurs and learn about their extremely unique (and often bizarre) products through visuals, a custom-made infomercial exclusively produced for the show, and by quizzing the business representative themselves. With the help of their celebrity advisors, the contestants must then decide who is selling an authentic product and who is hawking a sham. Correctly guessing the real deal gives the contestants the chance to win life-changing money.