The film opens in the year 1966, where a Soviet Scientist has come into the room where the volunteers for his experiment are kept only to find a horrific sight including zombie like creatures, the result of a stimulant that prevents sleep for 15 days. Horrified, the government hides the creatures away and denies any existence of these experiments, until today, when the creatures somehow escaped and began a terror across Moscow. Now a new Monster Squad, consisting of Blade, Morbius, Frankenstein, The Bride, Elsa Bloodstone, James P Sullivan, Mike Wazowski, Detective Chimp, The Lizard, Sabretooth, Wolf Man, Nightmare Nurse, G.I Robot, Tigra, Doctor Phosphorus, Ghost Roaster, John Coffey, and Man-Thing are sent to Moscow to stop the threat. There they are met by Colossus, Nightcrawler, Magik and Banshee, who were sent by Professor X, who thinks that the threat was released by an evil mutant geneticist named Mister Sinister, who is in works with Grigori Rasputin.
