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Susan "Mandark" Astronomanov is the main antagonist in Dexter's Laboratory. He is Dexter's rival and later mortal nemesis who often seeks to destroy both Dexter and his lab to prove once and for all that he is the superior genius.
Mandark Astronomonov
Obadiah Stane
for Obadiah Stane in The Marvel Universe....with Cartoon Network characters
Suggested by adamreece
The Marvel Universe, but with Cartoon Network characters