In April 1865, Pemberton sustained a saber wound to the chest during the Battle of Columbus. He soon became addicted to the morphine used to ease his pain.In 1866, seeking a cure for his addiction, he began to experiment with painkillers that would serve as morphine-free alternatives to morphine. His first recipe was "Dr. Tuggle's Compound Syrup of Globe Flower", in which the active ingredient was derived from the buttonbush (Cephalanthus occidentalis), a toxic plant. He next began experimenting with coca and coca wines, eventually creating a recipe that contained extracts of kola nut and damiana, which he called Pemberton's French Wine Coca.In 1886, when Atlanta and Fulton County enacted temperance legislation, Pemberton had to produce a non-alcoholic alternative to his French Wine Coca. Pemberton relied on Atlanta drugstore owner-proprietor Willis E. Venable to test, and help him perfect, the recipe for the beverage, which he formulated by trial and error. With Venable's assistance, Pemberton worked out a set of directions for its preparation.Pemberton died from stomach cancer at age 57 in August 1888. Then in 1892, Asa Griggs Candler establish the Coca Cola Company
