While fighting against the Justice League, the members of the Legion of Doom crash land on a vast island, yet unknown to most of humanity. In reality, they find themselves stuck under a high-tech dome, manipulated by a people of reptilians who have been living here for a long time. To escape, the greatest supervillains in the world will have to face these terrible warriors, but also the many very dangerous animals living on this island, which have nevertheless disappeared for a very long time on the rest of the planet ! In this true lost world, even the very dangerous members of the Legion of Doom are not safe from the horror of another era...