A colorful group of characters is called by the British Empire to form the so-called League of Extraordinary Gentlemen. Mina Murray, Allan Quatermain, Dr. Jekyll and Mr. Hyde, Captain Nemo and Hawley Griffin (the invisible man) are summoned by a sinister and suspicious individual, Mr. Bond, to carry out a mission that will save the Empire and the world. At the head of this whole organization, since Mr. Bond is only an intermediary, there is an elusive individual who calls himself "Mr. M". The six adventurers embark aboard the Nautilus on this mission against the infamous Doctor, a devilish Chinese in charge of all crime in London's East End, to thwart his plan for world conquest, but things are not really like. believed: the elusive Mr. M is actually James Moriarty, mistakenly believed dead, who intended to foil the Doctor's plans for the sole purpose of obtaining cavorite, a material that allows machines to fly, to use it on his war machine and conquer the world. The members of the League will therefore find themselves facing another threat they did not expect, still managing to get away with it and saving, for the second time, the Empire and the world.