In a post-apocalyptic future, the United States are ravaged by an outbrake of a mutant fungus that transforms its hosts into aggressive creatures, the Infected. Apparently, the young Ellie is immune, and she might be the cure of mankind's salvation. It's up to Joel to bring her to the Fireflies, a revolutionary militia group lead by Marlene, and develope a cure. But Joel and Ellie's journey won't be easy, in a broken world where men are often more dangerous than the Infected.
