20 years after a fungal pandemic ravaged America, Joel, a hardened survivor, is hired to smuggle Ellie, a young girl immune to the infection, through a dangerous post-apocalyptic world. Their journey becomes a test of survival and the development of their bond as they face ruthless factions and infected creatures. Joel and Ellie aim to reach the Fireflies, a group of rebels who hope to use Ellie's immunity to create a cure.