Nowadays, an author, a former soldier, named Edward Prendick is the sole survivor of a shipwreck, finding himself on an Island not shown on any map. In reality, it is owned by a very eccentric French scientist named Alphonse Moreau. The latter, with the help of his Scottish colleague, Doctor Bernard Mongtomery, succeeded in creating a race of beastmen, for whom Moreau considered himself a God. This both shocks and fascinates Prendick, notably becoming close to Moreau's most accomplished creation, nicknamed "La Féline", who is very intelligent and gifted, but wishes to see the world outside of her island. However, it is in an increasingly heavy atmosphere that Prendick will realize that among the beast men there are some who would like their independence, reminding him of quite a few humans he knows. The castaway will therefore have to choose his side or escape in time, because man definitely has a bad influence on everything he create...