After surviving a deadly gamma radiation accident, scientist Brooke Banner travels the world in search for a cure to her inner force of rage that turns her into a massive green monster known as the She-Hulk. Though she is close, Banner must watch out because the malevolent General Ross and her team are searching for her and want to use her condition for military weaponry. Running out of time and options, Banner turns to her old flame Brett Ross for help. Meanwhile, a new threat rises as a power hungry soldier turns into a deadlier and more terrifying beast that can match even the She*Hulk's powers.