When the Guardians of the Galaxy discover that Rocket Raccoon's creator, the High Evolutionary placed a cosmic equation in his DNA to destroy every living being in the universe, they must stop the High Evolutionary and his new test subject, Adam, from capturing Rocket to destroy all species from the universe and create a new "perfect" species, but the cruel Thanos also learns of the equation and sends his biological son, Thane, to hunt Rocket as well, putting the Guardians in a race against time.