A scientist called the High Evolutionary, the one who created Rocket Raccoon, has kidnapped Rocket Raccoon of the Guardians of the Galaxy and Invisible Woman of the Fantastic Four for his experiments.The remaining members of the Guardians of the Galaxy & the Fantastic Four join together to save their comrades. They are also joined by the Scarlet Witch & Quicksilver of the Avengers as they have a score to settle with the High Evolutionary as he was the one who gave them their powers and killed their real parents.