Batman is called by both Dr. Hugo Strange and Jeremiah Arkham to stop a mad riot at Arkham Asylum said to have been started by both the Joker and Two-Face. However, when he arrives, it soon becomes apparent that that's not the only reason he was called. As Batman and his friend Commissioner Gordon investigate, alongside the Joker strangely enough, they learn about the dark and troubled history of the Asylum and its founder Amadeus Arkham, Jeremiah Arkham's great grandfather.