Bruce Wayne is captured by Hugo Strange and is sent to Arkham City. Hugo knows Bruce is Batman and tells him that Protocol 10 is starting. Hugo has infected The Batman with a new virus, the Man-Bat virus, a modified serum based on Dr. Langstrom's original formula. He warns The Batman that if he isn't cured, then the virus will take over, transforming him into an unstable Man-Bat. The Batman must find a cure to the virus, instruct his allies to stop Hugo's TYGER outposts outside of the prison's walls, and face his dastardly rogues.