After the events of No Way Home Garfield's Spidey gets another chance regaining consciousness in the middle of a battle with Rhino. After this he faces animal themed thugs like tarantula, white rabbit, grizzly, gibbon, kangaroo, Armadillo and hippo as well as Donald Callahan and Dimitri Smerdyakov who sparks Harry Osborn's attention he makes squid and chameleon. Meanwhile Gwen's mom grieves over her demise and finds one of her swords from military days and starts to hunt down Spider Man. Chameleon proceeds to kill Gustav Fires and takes his identity squid questions if its right doing all the killing so chameleon leaves him for the police. Afterwards Coltheart strikes again but raids Harry Osborn's cell blaming both Peter & Harry but he and chameleon tricks her into joining them and they lure him to George Washington Bridge where after Spidey explains who he is she can't take it and throws herself off the bridge leaving Chameleon for the cops.
Then 2 weeks later his cousin hears of this and goes to san fran picking up some black goop along the way he leads a break out for many animal themes villains and puts them in central park. finding out Lizard lost his power somehow and regains a tested serum previously used on Iguana Man and the humanoid Vermin all being trapped in central park for hunting robots to destroy. But before that Oscorp scientist Adrian Toomes perfects his wingsuit and goes to ravage New York demanding respect he was denied for many years.
